Indiana University School of Medicine, Indianapolis, IN
Ph.D. Department of Microbiology and Immunology, 2003
Doctoral Candidate, 1999
Indiana University – Purdue University, Fort Wayne, IN Master’s of Biology Program
Indiana University, Bloomington, IN B.S. Biochemistry,
2006-current Secretary, Indiana Academy of Science
2008-current Council member, Autumn Immunology Conference
Current Associate Professor, Department of Biology, Ball State University
2002 Fall Lecturer, Mechanisms
of Immune Regulation, Indiana University School of Medicine
Course Instructor, Human Anatomy (Distance Learning, Video Instruction Course), Indiana University-Purdue University, Columbus IN
2001 Summer Content Editor, Microbiology Study Guide, The College Network, Indianapolis IN
1998 Summer Course Instructor, Microbiology Lab for Allied Health Professionals Indiana Univ-Purdue Ft Wayne
General Research and Interest Areas
Research focus in my lab:
1. Investigate aspects of oral tolerance
a. The effect of antibiotic treatment on intestinal probiotic populations and the induction of oral tolerance
b. The effect of esophageal inflammation on oral tolerance induction
2. Investigate the ability of herbal supplements to alter specific immune functions
Courses Currently Teaching
Bio 111 Introduction to Biology
Bio 344 Introduction to Immunology and Virology
Bio 631 Graduate Virology
Bio 636 Graduate Immunology
Stankiewicz TE; Haaning KL; Owens JM; Jordan AS; Gammon K; Bruns HA; McDowell SA. GTPase activating protein function of p85 facilitates uptake and recycling of the ß1 integrin. (2009) Biochemical and Biophysical Research Communications. 391(1):443-448
Crane ED, Stephenson N, Haffner C, Bruns HA. Active Immune Response Protects Stat6VT Transgenic Mice from Developing a Lymphoproliferative Disorder. (2009) Immunobiology. 215(7):579-585
Crane ED, Stephenson N, Haffner C, Bruns HA. Active Immune Response Protects Stat6VT Transgenic Mice from Developing a Lymphoproliferative Disorder. (2009) Immunobiology. In press.
Sehra S, Bruns HA, Ahyi AN, Nguyen ET, Michels EG, Schmidt NW, von Bülow GU and Kaplan MH. IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. (2008) J Immunol. 2008 Mar 1;180(5):3551-9.
Kaplan MH, Sehra S, Chang HC, O'Malley JT, Mathur AN, Bruns HA. Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. (2007) Blood. Dec 15;110(13):4367-9. Epub 2007 Sep 18.
Thieu VT, Nguyen ET, McCarthy BP, Bruns HA, Kapur R, Chang CH, Kaplan MH. IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. (2007) J Leukoc Biol. Aug;82(2):370-9. Epub 2007 May 18.
Bruns HA, Kaplan MH. The Role of Constitutively Active Stat6 Proteins in Leukemia and Lymphoma. (2006) Critical Reviews in Oncology/Hematology 57: 245-253.
Chang H-C, Zhang S, Thieu VT, Slee RB, Bruns HA, Laribee RN, Klemsz MJ, Kaplan MH. PU.1 expression delineates heterogeneity in primary Th2 cells. (2005) Immunity, 22: 693-703
Bruns HA, Schindler U, Kaplan MH. Expression of a Constitutively Active Stat6 in vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells. (2003) Journal of Immunology, 170: 3478-3487.
Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, and Kaplan MH. Th1 Cells Regulate Hematopoietic Progenitor Cell Homeostasis by Production of Oncostatin M. (2002) Immunity, 16: 815-825
Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham IL, Hoey T, Grusby MJ and Kaplan MH. Stat4 Regulates Multiple Components of IFNg Inducing Signaling Pathways. (2000) Journal of Immunology, 165: 6803-6808
American Association of Immunology (2000-present)
Indiana Branch of the American Society of Microbiology (2003-current)
Indiana Academy of Science (2003-present)
Spring 2009 Indiana Academy of Science “Examination of the immune response in Staphylococcus aureus-infected mice treated with simvastatin.”
Spring 2009 Ball State University, Sponsored Programs Office “Reduction of intestinal probiotic populations by antibiotic treatment during oral tolerization induces immune activation rather than suppression”
Spring 2008 Cancer Services of Delaware County “Exercise-induced Alterations in Immunoglobulin Levels in Cancer Versus Non-Cancer Patients”
Spring 2007 LillyV Institutional Funding, Ball State University “The Role of the Transcription Factor Stat6 in the Development of Leukemia and Lymphoma”
Spring 2006, Lilly V Grant Proposal, “The Role of the Transcription Factor Stat6 in the Development of Leukemia and Lymphoma” Award amount: $7,687.77
Spring 2005, Lilly V Grant Proposal, “Examination of Reduced T cell Numbers in Stat6VT Transgenic Mice” Award amount: $14,500 + $3869 supplemental
January 2005, Cancer Services of Delaware County – Little Red Door, “Immunological Examination of the Role of Stat6 in the Initiation and Progression of Lymphoma” Award amount: $3900
Summer 2004, Office of Academic Research and Sponsored Programs Summer Stipend Award, “The role of a mutated, constitutively active, Stat6 protein in lymphoma development” Award amount: Summer salary
January 2004, Nebraska State Department of Health, “Ehrlichia chaffeensis in Nebraska: Survey of deer for E. chaffeensis-reacting antibodies and assaying of ticks for E. chaffeensis” Award amount: $10,000 award, shared with Robert Pinger (Department of Physiology and Health Science)
Opportunities and Expectations in the Bruns Lab